Format

Send to

Choose Destination
Pharmacol Res. 2018 Aug;134:145-155. doi: 10.1016/j.phrs.2018.06.016. Epub 2018 Jun 18.

A bio-guided approach for the development of a chestnut-based proanthocyanidin-enriched nutraceutical with potential anti-gastritis properties.

Author information

1
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
2
E. Mach Foundation, Food Quality and Nutrition Department, San Michele all'Adige, TN, Italy.
3
Consorzio Castanicoltori di Brinzio, Orino e Castello Cabiaglio, Società Cooperativa Agricola-Varese, Italy.
4
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: emma.defabiani@unimi.it.
5
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy. Electronic address: mario.dellagli@unimi.it.

Abstract

Gastritis is a widely spread inflammatory disease, mostly caused by Helicobacter pylori infection. Release of IL-8 by the stomach epithelium is a hallmark of gastritis and contributes to the amplification of the inflammatory state. Pharmacological modulation of IL-8 release is a strategy to relieve gastric inflammation and prevent more severe clinical outcomes. In search of nutraceuticals with potential anti-gastritis properties we used a bio-guided approach based on IL-8 secretion by gastric cells to characterize extracts from the fruits of different chestnut varieties. We found that the ability to inhibit IL-8 secretion correlated with the amount of proanthocyanidins and was associated to the not edible parts of chestnut in all the tested varieties. We also found that the anti-inflammatory activity is preserved upon mild thermal treatment and after in vitro simulated gastric digestion. By combining a robust bio-guided approach with a comprehensive analysis of the tannin fraction of chestnut extracts, we provide evidence for the potential use of chestnut-based nutraceuticals in human gastritis. The bioactive components of chestnut fruits inhibit IL-8 secretion by impairing NF-κB signaling and by other mechanisms, thus opening new applications of proanthocyanidins for inflammation-based diseases.

KEYWORDS:

Chestnut; Gastric inflammation; Proanthocyanidins; interleukin-8

PMID:
29928974
DOI:
10.1016/j.phrs.2018.06.016

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center