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Telemed J E Health. 2019 Mar;25(3):237-242. doi: 10.1089/tmj.2018.0023. Epub 2018 Jun 21.

Validation of a Novel Telehealth Administration Protocol for the NIH Toolbox-Cognition Battery.

Author information

1
1 Faculty of Medicine, University of British Columbia, Vancouver, Canada.
2
2 Vancouver Stroke Program, Vancouver, Canada.
3
3 Doctors of BC, Vancouver, Canada.
4
4 Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, Canada.
5
5 Rehabilitation Research Program, Vancouver Coastal Health Research Institute, Vancouver, Canada.
6
6 Division of Neurology, University of British Columbia, Vancouver, Canada.
7
7 Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.

Abstract

BACKGROUND:

Cognition is an important outcome in many clinical trials. The NIH Toolbox-Cognition Battery (NIHTB-CB) is a computerized cognitive assessment designed for clinical research that is administered in-person. Here, we evaluated the equivalency of a novel videoconference protocol for administering the NIHTB-CB. Since our protocol required repeated assessments, we further explored the NIHTB-CB's practice effect.

MATERIALS AND METHODS:

Twenty-five healthy participants completed the NIHTB-CB under two separate conditions 4 weeks apart. The standard condition followed the recommended administration protocol, whereas the videoconference condition had the examiner and participant in separate rooms but able to communicate over videoconference. A linear mixed-model analysis was performed to explore the fixed effect of testing condition and time on NIHTB-CB performance.

RESULTS:

Across all three NIHTB-CB composite scores (total, fluid, and crystallized cognition), no significant fixed effect of administration condition was found. A significant practice effect was observed for the fluid and total cognition composite scores over a 29.0 (±2.1) day test-retest interval.

CONCLUSIONS:

Our novel videoconference protocol for the NIHTB-CB is equivalent to the standard protocol in healthy participants, and may provide a solution for researchers seeking to engage study participants at remote sites. If the NIHTB-CB is used longitudinally to monitor patients, corrections for repeated measures may be required.

KEYWORDS:

PMID:
29927713
DOI:
10.1089/tmj.2018.0023

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