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Curr Protoc Mouse Biol. 2018 Jun;8(2):e42. doi: 10.1002/cpmo.42. Epub 2018 May 21.

Generation and Identification of Mutations Resulting in Chronic and Age-Related Phenotypes in Mice.

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Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Oxford, United Kingdom.
Mary Lyon Centre, Medical Research Council Harwell Science and Innovation Campus, Oxford, United Kingdom.


Aging is inevitable, and our society must deal with the consequences: namely, an increased incidence of disease and ill health. Many mouse models of disease are acute or early onset or are induced in young mice, despite the fact that aging is a significant risk factor for a range of significant diseases. To improve modeling of such diseases, we should incorporate aging into our models. Many systems are affected by aging, with a decline in mitochondrial function, an increase in senescence, a loss of resilience, telomere shortening, and a decline in immune function being key factors in the increased susceptibility to disease that is associated with aging. To develop novel models of age-related disease, we undertook a phenotype-driven screen of a pipeline of mutagenized mice. Here, we describe some of the underlying protocols and outline important aspects to consider when studying aged mice.


age-related disease; ageing; mutagenesis; phenotyping

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