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Brain Imaging Behav. 2019 Aug;13(4):953-962. doi: 10.1007/s11682-018-9911-3.

12-h abstinence-induced functional connectivity density changes and craving in young smokers: a resting-state study.

Zhao S1,2, Li Y3,4, Li M5,6, Wang R5,6, Bi Y5,6, Zhang Y5,6, Lu X7, Yu D7, Yang L8, Yuan K9,10,11,12,13.

Author information

1
College of Computer Science and Information Technology, Guangxi Normal University, Guilin, Guangxi, 541004, People's Republic of China.
2
Guangxi Key Lab of Multi-Source Information Mining and Security, Guilin, Guangxi, 541004, People's Republic of China.
3
College of Computer Science and Information Technology, Guangxi Normal University, Guilin, Guangxi, 541004, People's Republic of China. lyd271@126.com.
4
Guangxi Key Lab of Multi-Source Information Mining and Security, Guilin, Guangxi, 541004, People's Republic of China. lyd271@126.com.
5
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China.
6
Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, People's Republic of China.
7
Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China.
8
Department of Neurosurgery, No 101 Hospital of Chinese PLA, Wuxi, People's Republic of China. beck_yang@163.com.
9
College of Computer Science and Information Technology, Guangxi Normal University, Guilin, Guangxi, 541004, People's Republic of China. kyuan@xidian.edu.cn.
10
Guangxi Key Lab of Multi-Source Information Mining and Security, Guilin, Guangxi, 541004, People's Republic of China. kyuan@xidian.edu.cn.
11
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China. kyuan@xidian.edu.cn.
12
Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, People's Republic of China. kyuan@xidian.edu.cn.
13
Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China. kyuan@xidian.edu.cn.

Abstract

Studying the neural correlates of craving to smoke is of great importance to improve treatment outcomes in smoking addiction. According to previous studies, the critical roles of striatum and frontal brain regions had been revealed in addiction. However, few studies focused on the hub of brain regions in the 12 h abstinence induced craving in young smokers. Thirty-one young male smokers were enrolled in the present study. A within-subject experiment design was carried out to compare functional connectivity density between 12-h smoking abstinence and smoking satiety conditions during resting state in young adult smokers by using functional connectivity density mapping (FCDM). Then, the functional connectivity density changes during smoking abstinence versus satiety were further used to examine correlations with abstinence-induced changes in subjective craving. We found young adult smokers in abstinence state (vs satiety) had higher local functional connectivity density (lFCD) and global functional connectivity density (gFCD) in brain regions including striatal subregions (i.e., bilateral caudate and putamen), frontal regions (i.e., anterior cingulate cortex (ACC) and orbital frontal cortex (OFC)) and bilateral insula. We also found higher lFCD during smoking abstinence (vs satiety) in bilateral thalamus. Additionally, the lFCD changes of the left ACC, bilateral caudate and right OFC were positively correlated with the changes in craving induced by abstinence (i.e., abstinence minus satiety) in young adult smokers. The present findings improve the understanding of the effects of acute smoking abstinence on the hubs of brain gray matter in the abstinence-induces craving and may contribute new insights into the neural mechanism of abstinence-induced craving in young smokers in smoking addiction.

KEYWORDS:

Abstinence-induced craving; Functional connectivity density mapping (FCDM); Resting state; Young adult smokers

PMID:
29926324
DOI:
10.1007/s11682-018-9911-3

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