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Open Biol. 2018 Jun;8(6). pii: 180049. doi: 10.1098/rsob.180049.

Multimodal sensory processing in Caenorhabditis elegans.

Author information

1
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Nikolaou Plastira 100, Heraklion 70013, Crete, Greece.
2
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Nikolaou Plastira 100, Heraklion 70013, Crete, Greece tavernarakis@imbb.forth.gr.
3
Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion 71110, Crete, Greece.

Abstract

Multisensory integration is a mechanism that allows organisms to simultaneously sense and understand external stimuli from different modalities. These distinct signals are transduced into neuronal signals that converge into decision-making neuronal entities. Such decision-making centres receive information through neuromodulators regarding the organism's physiological state and accordingly trigger behavioural responses. Despite the importance of multisensory integration for efficient functioning of the nervous system, and also the implication of dysfunctional multisensory integration in the aetiology of neuropsychiatric disease, little is known about the relative molecular mechanisms. Caenorhabditis elegans is an appropriate model system to study such mechanisms and elucidate the molecular ways through which organisms understand external environments in an accurate and coherent fashion.

KEYWORDS:

Caenorhabditis elegans; behavioural plasticity; interneuron; multisensory processing; sensory integration

PMID:
29925633
PMCID:
PMC6030117
DOI:
10.1098/rsob.180049
[Indexed for MEDLINE]
Free PMC Article

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