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J Agric Food Chem. 2018 Jul 18;66(28):7238-7248. doi: 10.1021/acs.jafc.8b01967. Epub 2018 Jul 9.

Food Allergen Epitope Mapping.

Author information

1
School of Exercise and Nutritional Sciences, College of Health and Human Services , San Diego State University , 308 ENS Building, 5500 Campanile Drive , San Diego , California 92182-7251 , United States.
2
Department of Nutrition, Food & Exercise Sciences, College of Human Sciences , Florida State University , 402 SAN, 120 Convocation Way , Tallahassee , Florida 32306-1493 , United States.

Abstract

With the increased global awareness and rise in food allergies, a multifold interest in food allergens is evident. The presence of undeclared food allergens results in expensive food recalls and increased risks of anaphylaxis for the sensitive individuals. Regardless of the allergenic food, the immunogen needs to be identified and detected before making any efforts to inactivate/eliminate it. In type I food allergies, protein immunogen cross-links immunoglobulin E, leading to basophil/mast cell degranulation, resulting in the symptoms that range from mild irritation to anaphylaxis. A portion/part of the protein, known as the epitope, can interact with either antibodies to elicit allergic reactions or T-cell receptors to initiate allergic sensitization. Antibody-recognized epitopes can be either a linear sequence of amino acids (linear epitope) or a three-dimensional motif (conformational epitope), while T-cell-receptor-recognized epitopes are exclusively linear peptides. Identifying and characterizing human-allergy-relevant epitopes are important for allergy diagnosis/prognosis, immunotherapy, and developing food processing methods that can reduce/eliminate immunogencity/immunoreactivity of the allergen.

KEYWORDS:

allergen; conformational; epitope mapping; food; linear; protein

PMID:
29924613
DOI:
10.1021/acs.jafc.8b01967
[Indexed for MEDLINE]

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