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Clin Pharmacol Ther. 2018 Jun 20. doi: 10.1002/cpt.1124. [Epub ahead of print]

Therapeutic Drug Monitoring in Oncology: IATDMCT Recommendations for 5-Fluorouracil Therapy.

Author information

1
Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
2
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
3
Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
4
University of Florida, Gainesville, FL.
5
Department of Clinical Pharmacokinetics and Pharmacodynamics, Keio University School of Medicine, Tokyo, Japan.
6
Oncopharmacology Unit, Centre Antoine Lacassagne, Nice, France.
7
Developmental Therapeutics Program, Mayo Clinic Cancer Center, Rochester, MN.
8
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic School of Medicine, Rochester, MN, USA.
9
Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
10
Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
11
Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
12
Department of Oncology, AK Altona, Asklepios Tumorzentrum Hamburg, Hamburg, Germany.
13
Division of Oncology Center, Niitsu Medical Center Hospital, Niigata City, Japan.
14
Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, Japan.
15
Department of Medical Oncology & Hematology, Cantonal Hospital, St. Gallen, Switzerland.

KEYWORDS:

5-fluorouracil; AUC; TDM; clinical benefit; colorectal cancer; drug exposure; plasma concentrations; response; squamous-cell cancer of the head and neck; therapeutic drug monitoring; toxicity

PMID:
29923599
DOI:
10.1002/cpt.1124

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