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Cytokine. 2018 Oct;110:397-403. doi: 10.1016/j.cyto.2018.06.021. Epub 2018 Jun 18.

Interleukin-5 suppresses Vascular Endothelial Growth Factor-induced angiogenesis through STAT5 signaling.

Author information

1
Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Germany.
2
Department of New Biology, DGIST, Daegu 42988, Republic of Korea.
3
Department of Brain-Cognitive Science, DGIST, Daegu 42988, Republic of Korea.
4
Division of Biotechnology, Chonbuk National University, Iksan 54596, Republic of Korea.
5
State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China.
6
Department of New Biology, DGIST, Daegu 42988, Republic of Korea. Electronic address: ykm31@dgist.ac.kr.

Abstract

Interleukin-5 (IL-5) is best known as key regulator in eosinophil-associated diseases such as asthma. While a connection to vascular changes in eosinophil-associated lung diseases is still elusive, recent evidence suggests that IL-5 may have an atheroprotective role. Here, we report an unexpected anti-angiogenic potential of IL-5 on vascular endothelial cells in vitro. IL-5 significantly inhibited fundamental functions of human lung microvascular endothelial cells (HMVEC-L) in vessel formation including VEGF-induced endothelial cell proliferation, migration and tube formation. Knockdown (KD) of STAT5 abolished the direct anti-angiogenic effect of IL-5 on VEGF-induced endothelial cell proliferation, migration and tube formation.

KEYWORDS:

Angiogenesis; Endothelial; Interleukin-5; STAT5; VEGF

PMID:
29921484
DOI:
10.1016/j.cyto.2018.06.021

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