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Toxicol Appl Pharmacol. 1985 Sep 15;80(2):199-205.

Changes in adrenal function as a possible mechanism for elevation of serum glucose by a single large dose of fluoride.

Abstract

Serum glucose was elevated immediately after ip administration of a single large dose of fluoride (NaF 35 mg/kg) to rats. Moreover, elevation of serum glucose following ip administration of 35 mg/kg of fluoride to rats was suppressed by adrenalectomy, dibenamine, or propranolol, but not by thyroid-parathyroidectomy. The elevation of serum glucose was associated with enhancement of glucose-6-phosphatase activities in liver and kidney in fluoride-treated rats.

PMID:
2992121
[Indexed for MEDLINE]

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