Send to

Choose Destination

The role of magnesium in pain.


Na HS3, Ryu JH3, Do SH3.


In: Vink R1, Nechifor M2, editors.


Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.

Author information

Discipline of Anatomy and Pathology & Adelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Department of Pharmacology, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.


Magnesium plays an important role in the prevention of central sensitization and in the attenuation of established pain hypersensitivity, and its main mode of action appears to involve its voltage-gated antagonist action at N-methyl-D-aspartate (NMDA) receptors. Given the putative function of the NMDA receptor in pain transduction, magnesium has been investigated in various clinical conditions associated with acute or chronic pain. The parenteral administration of magnesium, via an intravenous, intrathecal, or epidural route, may reduce pain, and anaesthetic and analgesic requirements during the intra- and post-operative periods. The beneficial effects of magnesium treatment have also been demonstrated in patients suffering from neuropathic pain, such as in those with malignancy-related neurologic symptoms, postherpetic neuralgia, diabetic neuropathy, and chemotherapy-induced peripheral neuropathy. In addition, magnesium therapy has been shown to be effective in alleviating dysmenorrhea, headaches, and acute migraine attacks. Magnesium is playing an evolving role in pain management, but a more thorough understanding of the mechanisms underlying its antinociceptive action and additional clinical studies are required to clarify its role as an analgesic adjuvant.

© 2011 The Authors.

Supplemental Content

Support Center