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Gigascience. 2018 Jun 1;7(6). doi: 10.1093/gigascience/giy071.

Consistent decreased activity in the putamen in Parkinson's disease: a meta-analysis and an independent validation of resting-state fMRI.

Wang J1,2,3,4, Zhang JR1,5, Zang YF2,3,4, Wu T1,5,6,7,8.

Author information

1
Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Institute of Geriatrics, No. 45, Changchun Rd, Xicheng District, 100053, Beijing, P. R. China.
2
Institutes of Psychological Sciences, Hangzhou Normal University, No. 2318, Yuhangtang Rd, Yuhang District, 311121, Hangzhou, P. R. China.
3
Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, No. 2318, Yuhangtang Rd, Yuhang District, 311121, Hangzhou, P. R. China.
4
Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, No. 2318, Yuhangtang Rd, Yuhang District, 311121, Hangzhou, P. R. China.
5
Clinical Center for Parkinson's Disease, Capital Medical University, No. 10, Youanmenwaixi Rd, Fengtai District, 100069, Beijing, P. R. China.
6
Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson's Disease Center of Beijing Institute for Brain Disorders, No. 45, Changchun Rd, Xicheng District, 100053, Beijing, P. R. China.
7
National Clinical Research Center for Geriatric Disorders, No. 45, Changchun Rd, Xicheng District, 100053, Beijing, P. R. China.
8
Parkinson Disease Imaging Consortium of China (PDICC), No. 45, Changchun Rd, Xicheng District, 100053, Beijing, P. R. China.

Abstract

Background:

Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to investigate local spontaneous brain activity in Parkinson's disease (PD) in a whole-brain, voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based (CB) meta-analysis using the signed differential mapping method on 15 studies that used amplitude of low-frequency fluctuation (ALFF) and 11 studies that used regional homogeneity (ReHo). All ALFF and ReHo studies compared PD patients with healthy controls. We also performed a validation RS-fMRI study of ALFF and ReHo in a frequency-dependent manner for a novel dataset consisting of 49 PD and 49 healthy controls.

Findings:

Decreased ALFF was found in the left putamen in PD by meta-analysis. This finding was replicated in our independent validation dataset in the 0.027-0.073 Hz band but not in the conventional frequency band of 0.01-0.08 Hz.

Conclusions:

Findings from the current study suggested that decreased ALFF in the putamen of PD patients is the most consistent finding. RS-fMRI is a promising technique for the precise localization of abnormal spontaneous activity in PD. However, more frequency-dependent studies using the same analytical methods are needed to replicate these results. Trial registration: NCT NCT03439163. Registered 20 February 2018, retrospectively registered.

PMID:
29917066
PMCID:
PMC6025187
DOI:
10.1093/gigascience/giy071
[Indexed for MEDLINE]
Free PMC Article

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