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Nat Neurosci. 2018 Jul;21(7):920-931. doi: 10.1038/s41593-018-0162-9. Epub 2018 Jun 18.

Optimization of interneuron function by direct coupling of cell migration and axonal targeting.

Author information

1
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
2
MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
3
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant, Spain.
4
Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
5
Center for Behavioral Brain Sciences, Institute of Cognitive Neurology and Dementia Research, German Center for Neurodegenerative Diseases, Otto-von-Guericke University, Magdeburg, Germany.
6
Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK.
7
Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. oscar.marin@kcl.ac.uk.
8
MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK. oscar.marin@kcl.ac.uk.
9
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant, Spain. oscar.marin@kcl.ac.uk.

Abstract

Neural circuit assembly relies on the precise synchronization of developmental processes, such as cell migration and axon targeting, but the cell-autonomous mechanisms coordinating these events remain largely unknown. Here we found that different classes of interneurons use distinct routes of migration to reach the embryonic cerebral cortex. Somatostatin-expressing interneurons that migrate through the marginal zone develop into Martinotti cells, one of the most distinctive classes of cortical interneurons. For these cells, migration through the marginal zone is linked to the development of their characteristic layer 1 axonal arborization. Altering the normal migratory route of Martinotti cells by conditional deletion of Mafb-a gene that is preferentially expressed by these cells-cell-autonomously disrupts axonal development and impairs the function of these cells in vivo. Our results suggest that migration and axon targeting programs are coupled to optimize the assembly of inhibitory circuits in the cerebral cortex.

PMID:
29915195
PMCID:
PMC6061935
DOI:
10.1038/s41593-018-0162-9
[Indexed for MEDLINE]
Free PMC Article

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