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Trends Neurosci. 2018 Aug;41(8):526-539. doi: 10.1016/j.tins.2018.05.003. Epub 2018 Jun 18.

Peripheral and Central Nutrient Sensing Underlying Appetite Regulation.

Author information

1
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
2
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. Electronic address: yoka@caltech.edu.

Abstract

The precise regulation of fluid and energy homeostasis is essential for survival. It is well appreciated that ingestive behaviors are tightly regulated by both peripheral sensory inputs and central appetite signals. With recent neurogenetic technologies, considerable progress has been made in our understanding of basic taste qualities, the molecular and/or cellular basis of taste sensing, and the central circuits for thirst and hunger. In this review, we first highlight the functional similarities and differences between mammalian and invertebrate taste processing. We then discuss how central thirst and hunger signals interact with peripheral sensory signals to regulate ingestive behaviors. We finally indicate some of the directions for future research.

KEYWORDS:

hunger; sensory valence; taste; thirst; top-down regulation

PMID:
29914721
PMCID:
PMC6064385
[Available on 2019-08-01]
DOI:
10.1016/j.tins.2018.05.003
[Indexed for MEDLINE]

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