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Nutr Res. 2018 Jul;55:65-71. doi: 10.1016/j.nutres.2018.04.012. Epub 2018 Apr 21.

Dietary flavonoids improve urinary arsenic elimination among Mexican women.

Author information

1
Center for Research in Population Health, National Institute of Public Health, Cuernavaca, Morelos, México; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, U.S.A.; Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, U.S.A.
2
Center for Research in Population Health, National Institute of Public Health, Cuernavaca, Morelos, México.
3
Department of Toxicology, CINVESTAV, Ciudad de México, Ciudad de México, México.
4
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, U.S.A.
5
Department of Research in Epidemiology and Social Sciences in Health, National Institute of Respiratory Diseases, Ciudad de México, Ciudad de México, México.
6
Center for Research in Population Health, National Institute of Public Health, Cuernavaca, Morelos, México. Electronic address: lizbeth@insp.mx.

Abstract

Inorganic arsenic (iAs) exposure increases risk of several diseases, including cancer. Some nutrients such as flavonoids enhance glutathione activity, which in turn play a key role in iAs elimination. Our objective was to explore whether dietary non-soy flavonoids are associated with iAs metabolism. We hypothesized that the intake of flavonoids belonging to the following groups, flavan-3-ols, flavone, flavonol, flavanone, and anthocyanidin, is positively associated with urinary dimethylarsinic acid (DMA), which is the most soluble iAs metabolite excreted. We performed a cross-sectional study that included 1027 women living in an arsenic-contaminated area of northern Mexico. Flavonoid intake was estimated using a validated food frequency questionnaire. Concentration of urinary iAs and its metabolites (monomethylarsonic acid and DMA) were determined by high performance liquid chromatography ICP-MS. Results showed positive significant associations between DMA and the flavonoid groups flava-3-ols (β= 0.0112) and flavones (β= 0.0144), as well as the individual intake of apigenin (β= 0.0115), luteolin (β= 0.0138), and eriodictyol (β= 0.0026). Our findings suggest that certain non-soy flavonoids may improve iAs elimination; however, there is still very limited information available regarding the consumption of flavonoids and iAs metabolism.

KEYWORDS:

Arsenic metabolism; Cross-sectional study; Flavonoids; Mexico

PMID:
29914629
PMCID:
PMC6011230
[Available on 2019-07-01]
DOI:
10.1016/j.nutres.2018.04.012

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