Format

Send to

Choose Destination
Nutrients. 2018 Jun 15;10(6). pii: E774. doi: 10.3390/nu10060774.

Habitual Fructose Intake Relates to Insulin Sensitivity and Fatty Liver Index in Recent-Onset Type 2 Diabetes Patients and Individuals without Diabetes.

Author information

1
Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany. katharina.weber@ddz.uni-duesseldorf.de.
2
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. katharina.weber@ddz.uni-duesseldorf.de.
3
Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany. marie-christine.simon@uni-bonn.de.
4
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. marie-christine.simon@uni-bonn.de.
5
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. klaus.strassburger@ddz.uni-duesseldorf.de.
6
Institute for Biometrics and Epidemiology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany. klaus.strassburger@ddz.uni-duesseldorf.de.
7
Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany. daniel.markgraf@ddz.uni-duesseldorf.de.
8
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. daniel.markgraf@ddz.uni-duesseldorf.de.
9
Institute of Nutrition, Consumption and Health, Faculty of Natural Sciences, University Paderborn, 33098 Paderborn, Germany. anette.buyken@uni-paderborn.de.
10
Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany. julia.szendroedi@ddz.uni-duesseldorf.de.
11
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. julia.szendroedi@ddz.uni-duesseldorf.de.
12
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. julia.szendroedi@ddz.uni-duesseldorf.de.
13
Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany. karsten.muessig@ddz.uni-duesseldorf.de.
14
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. karsten.muessig@ddz.uni-duesseldorf.de.
15
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. karsten.muessig@ddz.uni-duesseldorf.de.
16
Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Institute for Diabetes Research, 40225 Düsseldorf, Germany. michael.roden@ddz.uni-duesseldorf.de.
17
German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. michael.roden@ddz.uni-duesseldorf.de.
18
Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. michael.roden@ddz.uni-duesseldorf.de.

Abstract

The association between the amount and sources of fructose intake with insulin sensitivity and liver fat needs further elucidation. This study aimed at examining whether habitual intake of sucrose plus non-sucrose bound as well as of non-sucrose bound fructose (total fructose, fruit-derived, juice-derived, sugar sweetened beverages (SSB)-derived fructose) is cross-sectionally associated with insulin sensitivity and fatty liver index (FLI). Fructose intake was estimated using the EPIC food frequency questionnaire from 161 participants with type 2 diabetes (T2D) in the ongoing German Diabetes Study (GDS) (age 53 ± 9 years; HbA1c 6.4 ± 0.9%) and 62 individuals without diabetes (CON) (47 ± 14 years; 5.3 ± 0.3%). Peripheral (M-value) and hepatic insulin resistance were assessed by hyperinsulinemic-euglycemic clamps with stable isotope dilution. FLI was calculated based on body mass index, waist circumference, triglyceride and gamma glutamyl transferase concentrations. Multivariable linear regression analyses were performed. A doubling of SSB-derived sucrose plus non-sucrose bound as well as of non-sucrose bound fructose intake was independently associated with a reduction of the M-value by -2.6% (-4.9; -0.2) and -2.7% (-5.2; -0.1) among T2D, respectively, with an increase in the odds of fatty liver by 16% and 17%, respectively among T2D (all p < 0.05). Doubling fruit-derived sucrose plus non-sucrose bound fructose intake independently related to a reduction in the odds of fatty liver by 13% (p = 0.033) among T2D. Moderate SSB-derived fructose intake may detrimentally affect peripheral insulin sensitivity, whereas fruit-derived fructose intake appeared beneficial for liver fat content.

KEYWORDS:

dietary fructose; hepatic insulin sensitivity; observational cohort study; peripheral insulin sensitivity

PMID:
29914103
PMCID:
PMC6024554
DOI:
10.3390/nu10060774
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center