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J Alzheimers Dis. 2018;64(2):355-362. doi: 10.3233/JAD-180191.

Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort.

Author information

1
Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
2
UCL Genomics, UCL Genomics Great Ormond Street Institute of Child Health, London, UK.
3
Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
4
Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal.
5
UK Dementia Research Institute at UCL (UK DRI), London, UK.
6
King's College London, Wolfson Centre for Age Related Diseases, London, UK.

Abstract

The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer's disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOEɛ4 allele was identified (p = 3.99×10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al. GWAS meta-analysis was observed.

KEYWORDS:

Alzheimer’s disease; Brains for Dementia Research; association; genome-wide association study; single nucleotide polymorphisms

PMID:
29914034
DOI:
10.3233/JAD-180191
[Indexed for MEDLINE]

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