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FASEB J. 2018 Sep;32(9):5039-5050. doi: 10.1096/fj.201701503RR. Epub 2018 Apr 17.

Maternal folic acid supplementation with vitamin B12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet.

Author information

1
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
2
British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
3
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
4
Department of Food, Nutrition, and Health, University of British Columbia, Vancouver, British Columbia, Canada.
5
Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
6
Department of Nutritional Sciences, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey, USA.
7
South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Abstract

Epidemiologic studies have reported relationships between maternal high folate and/or low B12 status during pregnancy and greater adiposity and insulin resistance in children. The goal of this study was to determine the effects of maternal folic acid supplementation (10 mg/kg diet), with (50 μg/kg diet) and without B12, on adult female offspring adiposity and glucose homeostasis. Female C57BL/6J mice were fed 1 of 3 diets from weaning and throughout breeding, pregnancy, and lactation: control (2 mg/kg diet folic acid, 50 μg/kg diet B12), supplemental folic acid with no B12 (SFA-B12), or supplemental folic acid with adequate B12 (SFA+B12). Female offspring were weaned onto the control diet or a Western diet (45% energy fat, 2 mg/kg diet folic acid, 50 μg/kg diet B12) for 35 wk. After weaning, control diet-fed offspring with SFA-B12 dams had fasting hyperglycemia, glucose intolerance, lower β cell mass, and greater islet hepatocyte nuclear factor 1 homeobox α and nuclear receptor subfamily 1 group H member 3 mRNA than did offspring from control dams. In Western diet-fed offspring, those with SFA-B12 dams had lower fasting blood glucose and plasma insulin concentrations, and were smaller than control offspring. Our findings suggest that maternal folic acid supplementation with B12 deficiency during pregnancy/lactation programs the metabolic health of adult female offspring but is dependent on offspring diet.-Henderson, A. M., Tai, D. C., Aleliunas, R. E., Aljaadi, A. M., Glier, M. B., Xu, E. E., Miller, J. W., Verchere, C. B., Green, T. J., Devlin, A. M. Maternal folic acid supplementation with vitamin B12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet.

KEYWORDS:

adiposity; developmental programming; folate; glucose homeostasis; maternal diet

PMID:
29913560
DOI:
10.1096/fj.201701503RR
[Indexed for MEDLINE]

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