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Cell Metab. 2018 Aug 7;28(2):207-216.e3. doi: 10.1016/j.cmet.2018.05.020. Epub 2018 Jun 14.

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis.

Author information

1
Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
2
Department of Medical Physics, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa, Japan.
3
Chair of Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Technical University of Munich, 85354 Freising, Germany.
4
University Côte d'Azur, CNRS, Inserm, iBV, Nice, France.
5
Chair of Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Technical University of Munich, 85354 Freising, Germany; ZIEL - Institute for Food and Health, Technical University of Munich, 85354 Freising, Germany.
6
Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Department of Chemistry, University of Turku, Turku, Finland; Accelerator Laboratory, Åbo Akademi University, Turku, Finland.
7
Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Department of Endocrinology, Turku University Hospital, Turku, Finland.
8
Turku PET Centre, Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland; Institute of Public Health and Clinical Nutrition, University of Eastern Finland (UEF), Kuopio, Finland. Electronic address: kirsi.virtanen@utu.fi.

Abstract

Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We identified several genes participating in lipid metabolism to be expressed at higher levels in BAT compared with white fat in postprandial state, and to be positively correlated with BAT UCP1 expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.

KEYWORDS:

brown fat; human; meal-induced thermogenesis; oxidative metabolism; positron emission tomography; postprandial metabolism

PMID:
29909972
DOI:
10.1016/j.cmet.2018.05.020
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