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Cell Metab. 2018 Jul 3;28(1):33-44.e3. doi: 10.1016/j.cmet.2018.05.018. Epub 2018 Jun 14.

Supra-Additive Effects of Combining Fat and Carbohydrate on Food Reward.

Author information

1
Max Planck Institute for Metabolism Research, 50931 Cologne, Germany; John B. Pierce Laboratory, New Haven, CT 06519, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA; Modern Diet and Physiology Research Center, New Haven, CT 06519, USA.
2
Max Planck Institute for Metabolism Research, 50931 Cologne, Germany; Swiss Center for Affective Sciences, Geneva 1202, Switzerland; E3 Lab, University of Geneva, Geneva 1205, Switzerland.
3
Max Planck Institute for Metabolism Research, 50931 Cologne, Germany; Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich 8032, Switzerland.
4
Max Planck Institute for Metabolism Research, 50931 Cologne, Germany; Department of Neurology, University Hospital of Cologne, 50931 Cologne, Germany.
5
Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada; Modern Diet and Physiology Research Center, New Haven, CT 06519, USA.
6
Max Planck Institute for Metabolism Research, 50931 Cologne, Germany; Modern Diet and Physiology Research Center, New Haven, CT 06519, USA.
7
John B. Pierce Laboratory, New Haven, CT 06519, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA; Modern Diet and Physiology Research Center, New Haven, CT 06519, USA. Electronic address: dana.small@yale.edu.

Abstract

Post-ingestive signals conveying information about the nutritive properties of food are critical for regulating ingestive behavior. Here, using an auction task concomitant to fMRI scanning, we demonstrate that participants are willing to pay more for fatĀ + carbohydrate compared with equally familiar, liked, and caloric fat or carbohydrate foods and that this potentiated reward is associated with response in areas critical for reward valuation, including the dorsal striatum and mediodorsal thalamus. We also show that individuals are better able to estimate the energy density of fat compared with carbohydrate and fatĀ + carbohydrate foods, an effect associated with functional connectivity between visual (fusiform gyrus) and valuation (ventromedial prefrontal cortex) areas. These results provide the first demonstration that foods high in fat and carbohydrate are, calorie for calorie, valued more than foods containing only fat or carbohydrate and that this effect is associated with greater recruitment of central reward circuits.

KEYWORDS:

carbohydrate; dopamine; fMRI; fat; food reward; gut-brain axis; neural circuits; reinforcement; striatum; value

PMID:
29909968
DOI:
10.1016/j.cmet.2018.05.018

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