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Nat Commun. 2018 Jun 15;9(1):2352. doi: 10.1038/s41467-018-04576-z.

Single-breath-hold photoacoustic computed tomography of the breast.

Author information

1
Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA, 91125, USA.
2
Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Dr., St. Louis, MO, 63130, USA.
3
Breast Imaging Section, Washington University School of Medicine in St. Louis, 510 South Kingshighway Blvd, St. Louis, MO, 63108, USA.
4
Caltech Optical Imaging Laboratory, Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA, 91125, USA.
5
Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA, 91125, USA. LVW@caltech.edu.
6
Caltech Optical Imaging Laboratory, Department of Electrical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA, 91125, USA. LVW@caltech.edu.

Abstract

We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scanning the entire breast within a single breath hold (~15 s), a volumetric image can be acquired and subsequently reconstructed utilizing 3D back-projection with negligible breathing-induced motion artifacts. SBH-PACT clearly reveals tumors by observing higher blood vessel densities associated with tumors at high spatial resolution, showing early promise for high sensitivity in radiographically dense breasts. In addition to blood vessel imaging, the high imaging speed enables dynamic studies, such as photoacoustic elastography, which identifies tumors by showing less compliance. We imaged breast cancer patients with breast sizes ranging from B cup to DD cup, and skin pigmentations ranging from light to dark. SBH-PACT identified all the tumors without resorting to ionizing radiation or exogenous contrast, posing no health risks.

PMID:
29907740
PMCID:
PMC6003984
DOI:
10.1038/s41467-018-04576-z
[Indexed for MEDLINE]
Free PMC Article

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