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Anal Chim Acta. 2018 Oct 31;1029:44-49. doi: 10.1016/j.aca.2018.05.004. Epub 2018 May 4.

Normal-inverse bimodule operation Hadamard transform ion mobility spectrometry.

Author information

1
Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, China; School of Electrical and Information Engineering, Anhui University of Science and Technology, Huainan, Anhui, China.
2
Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, China. Electronic address: cqhuang@aiofm.ac.cn.
3
College of Computer Science and Technology, Huaibei Normal University, Huaibei, Anhui, China.
4
Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, China.

Abstract

In order to suppress or eliminate the spurious peaks and improve signal-to-noise ratio (SNR) of Hadamard transform ion mobility spectrometry (HT-IMS), a normal-inverse bimodule operation Hadamard transform - ion mobility spectrometry (NIBOHT-IMS) technique was developed. In this novel technique, a normal and inverse pseudo random binary sequence (PRBS) was produced in sequential order by an ion gate controller and utilized to control the ion gate of IMS, and then the normal HT-IMS mobility spectrum and the inverse HT-IMS mobility spectrum were obtained. A NIBOHT-IMS mobility spectrum was gained by subtracting the inverse HT-IMS mobility spectrum from normal HT-IMS mobility spectrum. Experimental results demonstrate that the NIBOHT-IMS technique can significantly suppress or eliminate the spurious peaks, and enhance the SNR by measuring the reactant ions. Furthermore, the gas CHCl3 and CH2Br2 were measured for evaluating the capability of detecting real sample. The results show that the NIBOHT-IMS technique is able to eliminate the spurious peaks and improve the SNR notably not only for the detection of larger ion signals but also for the detection of small ion signals.

KEYWORDS:

Hadamard transform; Ion mobility spectrometry; Signal-to-noise ratio; Spurious peaks

PMID:
29907289
DOI:
10.1016/j.aca.2018.05.004

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