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J Am Acad Dermatol. 2018 Nov;79(5):831-835. doi: 10.1016/j.jaad.2018.06.004. Epub 2018 Jun 13.

Association between Breslow thickness and dermoscopic findings in acral melanoma.

Author information

1
Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, South Korea.
2
Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.
3
Department of Dermatology, Chonbuk National University Medical School, Jeonju, South Korea.
4
Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
5
Department of Dermatology, Pusan National University College of Medicine, Busan, South Korea.
6
Department of Dermatology, Pusan National University College of Medicine, Busan, South Korea; Medical Research Institute, Pusan National University Hospital, Busan, South Korea. Electronic address: drkmp@hanmail.net.

Abstract

BACKGROUND:

Dermoscopy is a useful tool for the diagnosis of acral melanomas (AMs). However, little is known about the influence of tumor thickness on the dermoscopic findings of AM.

OBJECTIVE:

To investigate the affect Breslow thickness (BT) has on the dermoscopic patterns of AM.

METHODS:

Data on cases of AM on the glabrous skin were collected from 4 university hospitals. We investigated the frequency of each dermoscopic feature of AM according to the BT. Statistical analysis was performed to investigate the association between the specific dermoscopic patterns and BT.

RESULTS:

Multivariable analysis revealed that the colors red (odds ratio [OR] 16.482, 95% confidence interval [CI] 3.605-99.016); blue (OR 7.092; 95% CI 1.707-37.435); and white (OR 5.048, 95% CI 1.152-22.897) were more common in AM with BT >2 mm than those with BT ≤2 mm. Regarding patterns, atypical vascular (OR 34.589, 95% CI 6.458-305.852); blue-white veils (OR 9.605, 95% CI 1.971-72.062); and ulcers (OR 5.084, 95% CI 1.145-24.152) were more frequently detected in cases with BT >2 mm than those with BT ≤2 mm.

LIMITATIONS:

A retrospective study design and small sample size.

CONCLUSION:

This study showed an association between dermoscopic patterns and tumor thickness among patients with AM. Dermoscopy can be a useful adjuvant tool for predicting BT in AM.

KEYWORDS:

Breslow thickness; acral melanoma; depth; dermoscopy; diagnosis; melanoma; prognosis

PMID:
29906546
DOI:
10.1016/j.jaad.2018.06.004
[Indexed for MEDLINE]

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