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Physiol Genomics. 2018 Sep 1;50(9):724-725. doi: 10.1152/physiolgenomics.00141.2017. Epub 2018 Jun 15.

GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study.

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Section of Biomedical Genetics, Boston University School of Medicine and The Department of Biostatistics, Boston University School of Public Health , Boston, Massachusetts.
Department of Pharmacology & Experimental Therapeutics and The Whitaker Cardiovascular Institute, Boston University School of Medicine , Boston, Massachusetts.
Division of Endocrinology, Diabetes, Hypertension, Brigham and Women's, Harvard Medical School , Boston, Massachusetts.


Salt sensitivity of blood pressure (BP) increases hypertension risk and associated adverse cardiovascular outcomes. At present, there are no validated rapid tests or diagnostic markers to identify salt sensitivity of BP in clinical practice. Based on our prior animal studies that report a role for brain Gαi2 proteins in the salt sensitivity of BP and evidence that GNAI2 single nucleotide polymorphisms (SNPs) associate with hypertension risk, we investigated the hypothesis that GNAI2 SNPs associate with salt sensitivity of BP in humans. Our data provide the first evidence that a GNAI2 SNP ( rs10510755 ) positively associates with salt sensitivity of BP in the Genetic Epidemiology of Salt Sensitivity data set (continuous phenotype P = 0.049, case-control phenotype P = 0.039; n = 968), independently of subject sex or age. These observations suggest that genotyping at GNAI2 may be a useful biomarker in identifying individuals at risk for developing salt-sensitive BP and related complications or in identifying salt sensitivity within the hypertensive population.


GNAI2; Gαi2 proteins; rs10510755; salt sensitivity of blood pressure

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