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F1000Res. 2018 Jun 1;7. pii: F1000 Faculty Rev-689. doi: 10.12688/f1000research.14127.1. eCollection 2018.

Indole-3-carbinol: a plant hormone combatting cancer.

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1
School of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, Israel.
2
Department of Plant Sciences, University of California , Davis , USA.

Abstract

A diet rich in cruciferous vegetables such as cauliflower, broccoli, and cabbage has long been considered healthy, and various epidemiological studies suggest that the consumption of cruciferous vegetables contributes to a cancer-protecting diet. While these vegetables contain a vast array of phytochemicals, the mechanism by which these vegetables counteract cancer is still largely unresolved. Numerous in situ studies have implicated indole-3-carbinol, a breakdown product of the glucosinolate indole-3-ylmethylglucosinolate, as one of the phytochemicals with anti-cancer properties. Indole-3-carbinol influences a range of cellular processes, but the mechanisms by which it acts on cancer cells are slowly being revealed. Recent studies on the role of indole-3-carbinol in Arabidopsis opens the door for cross-kingdom comparisons that can help in understanding the roles of this important phytohormone in both plant biology and combatting cancer.

KEYWORDS:

cancer prevention; cruciferous vegetables; glucosinolates; indole-3-carbinol

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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