Format

Send to

Choose Destination
Nat Rev Microbiol. 2018 Jun 14. doi: 10.1038/s41579-018-0036-x. [Epub ahead of print]

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier.

Author information

1
University of Michigan Medical School, Ann Arbor, MI, USA. emartens@umich.edu.
2
Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
3
Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg. mahesh.desai@lih.lu.
4
Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark. mahesh.desai@lih.lu.

Abstract

The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.

PMID:
29904082
DOI:
10.1038/s41579-018-0036-x

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center