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Cytokine. 2018 Sep;109:57-64. doi: 10.1016/j.cyto.2018.02.010.

Chemokines in breast cancer: Regulating metabolism.

Author information

1
Dept. Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Bldg., Toronto, Ontario M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, Ontario M5G 2M1, Canada. Electronic address: darrin.gao@mail.utoronto.ca.
2
Dept. Immunology, University of Toronto, 1 King's College Circle, Medical Sciences Bldg., Toronto, Ontario M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, Ontario M5G 2M1, Canada. Electronic address: en.fish@utoronto.ca.

Abstract

Accumulating evidence indicates that chemokine-chemokine receptor interactions invoke biological responses beyond their originally described function of orchestrating leukocyte trafficking. In this review we will extend the findings that chemokines participate actively in the neoplastic process, and consider the contribution of CCL5 activation of CCR5 on breast cancer cells to upregulation of anabolic metabolic events that would support the energy demands of cell replication and proliferation.

PMID:
29903574
DOI:
10.1016/j.cyto.2018.02.010

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