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Steroids. 2018 Oct;138:21-25. doi: 10.1016/j.steroids.2018.06.005. Epub 2018 Jun 15.

Penicisteroid C: New polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger.

Author information

1
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Microbial Chemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, El-Buhouth St. 33, Dokki, Cairo 12622, Egypt.
2
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
3
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany.
4
Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, El-Buhouth St. 33, Dokki, Cairo 12622, Egypt. Electronic address: mshaaba@gmail.com.

Abstract

Penicisteroid C, a new polyoxygenated steroid was isolated from co-cultivation of Streptomyces piomogenus AS63D and Aspergillus niger using solid-state fermentation on rice medium. Additional diverse eleven known metabolites were identified: Fumigaclavine C, fumiquinazoline C, physcion, methylsulochrin, methyllinoleate, glycerol linoleate, cerebroside A, thymine, adenine, thymidine and adenosine. The structure of penicisteroid C was determined by HRESIMS, 1D and 2D NMR data. The antimicrobial and in vitro cytotoxic activities of the microbial extract and penicisteroid C were reported as well.

KEYWORDS:

Antimicrobial activity; Aspergillus niger; Co-cultivation; Cytotoxicity; Penicisteroid C; Sterol; Streptomyces piomogenus

PMID:
29902496
DOI:
10.1016/j.steroids.2018.06.005
[Indexed for MEDLINE]

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