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Indian J Dent Res. 2018 May-Jun;29(3):333-340. doi: 10.4103/ijdr.IJDR_184_17.

Expression of vimentin and CD44 in mucoepidermoid carcinoma: A role in tumor growth.

Author information

1
Dental Research Center, Department of Oral Pathology, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Pathology, School of Medicine, Griffith University, Gold Coast, Australia.
2
Department of Pathology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Background:

Cancer stem cells (CSCs) may participate in angiogenesis by lining the wall of tumor vessels.

Aim:

The current study aimed to present the role of vimentin and CD44 in inducing vasculogenic mimicry (VM) and epithelial-mesenchymal transition (EMT) in different grades of mucoepidermoid carcinoma (MEC).

Materials and Methods:

A total of 63 MEC samples were collected from the archive of Department of Pathology of Taleghani Educational Hospital, Tehran, Iran. Vimentin and CD44/periodic acid-Schiff double staining was performed.

Statistical Analysis:

Chi-square test was used to examine the differences with categorical variables. Significance level was set at 0.05. Pearson's correlation coefficient was used to assess the colocalization of the markers.

Results:

There were statistically significant differences between tumor grade and the expression levels of vimentin and CD44 (P = 0.000).

Conclusion:

Our results may disclose a definite relationship between microvessl density (MVD), VM, EMT, and CSCs in MEC samples. Thus, it is reasonable to suggest that CSCs are related to angiogenesis and VM.

KEYWORDS:

Angiogenesis; CD44; mucoepidermoid carcinoma; vimentin

PMID:
29900918
DOI:
10.4103/ijdr.IJDR_184_17
[Indexed for MEDLINE]
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