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Data Brief. 2018 Mar 17;18:594-606. doi: 10.1016/j.dib.2018.03.045. eCollection 2018 Jun.

Datasets describing the growth and molecular features of hepatocellular carcinoma patient-derived xenograft cells grown in a three-dimensional macroporous hydrogel.

Author information

1
Department of Biomedical Engineering, National University of Singapore, Singapore.
2
Cancer Science Institute of Singapore, National University of Singapore, Singapore.
3
Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (ASTAR) Singapore.
4
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
5
National Cancer Center Singapore, Singapore.
6
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
7
Mechanobiology Institute, National University of Singapore, Singapore.
8
BioSyM, Singapore-MIT Alliance for Research and Technology, Singapore.
9
Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
10
NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore.

Abstract

This data article presents datasets associated with the research article entitled "Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer" (Fong et al., 2018) [1]. A three-dimensional macroporous sponge system was used to generate in vitro counterparts to various hepatocellular carcinoma patient-derived xenograft (HCC-PDX) lines. This article describes the viability, proliferative capacity and molecular features (genomic and transcriptomic profiles) of the cultured HCC-PDX cells. The sequencing datasets are made publicly available to enable critical or further analyzes.

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