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Front Neurol. 2018 May 30;9:394. doi: 10.3389/fneur.2018.00394. eCollection 2018.

Early Gray Matter Volume Loss in MAPT H1H1 de Novo PD Patients: A Possible Association With Cognitive Decline.

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Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Biomedical Research Institute (IIB-Sant Pau), Barcelona, Spain.
Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Madrid, Spain.


The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. Importantly, these changes were associated with a longitudinal worsening of cognitive indicators. Our findings suggest that early GMV loss in MAPT H1H1 PD patients increases their risk to develop cognitive decline.


MAPT; Parkinson's disease; T1-MRI; cognitive decline; gray matter volume

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