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Prog Clin Biol Res. 1985;178:103-7.

Subclinical and clinical bluetongue disease in cattle: clinical, pathological and pathogenic considerations.

Abstract

Calves immunized (sensitized) with alcide-inactivated bluetongue virus (BTV) developed immunoglobulin (Ig) E-specific antibody to BTV. Development of clinically apparent disease occurred after challenge with virulent BTV, and lesions correlated with peak levels of virus-specific IgE, an eosinophilic dermatitis, and high concentrations of histamine in the skin. IgE may be important in the pathogenesis of clinical bluetongue (BT) disease in cattle.

PMID:
2989843
[Indexed for MEDLINE]
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