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Tissue Eng Part B Rev. 2018 Oct;24(5):392-402. doi: 10.1089/ten.TEB.2017.0508.

Biomechanical Stimulus Based Strategies for Meniscus Tissue Engineering and Regeneration.

Author information

1
1 Institute of Orthopedics , Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, People's Republic of China .
2
2 Department of Orthopedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, 100035 Beijing, People's Republic of China .
3
3 Center for Biomaterial and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University , Beijing, People's Republic of China .
4
4 Institute of Anesthesiology , Chinese PLA General Hospital, Beijing, People's Republic of China .
5
5 Department of Bone and Joint Surgery, The Affiliated Hospital of Southwest Medical University , Luzhou, People's Republic of China .
6
6 First Department of Orthopedics, First Affiliated Hospital of Jiamusi University , Jiamusi, People's Republic of China .
7
7 School of Medicine, Nankai University , Tianjin, People's Republic of China .
8
8 Shanxi Traditional Chinese Hospital , Taiyuan, People's Republic of China .

Abstract

Meniscus injuries are very common in the knee joint. Treating a damaged meniscus continues to be a scientific challenge in sport medicine because of its poor self-healing potential and few clinical therapeutic options. Tissue engineering strategies are very promising solutions for repairing and regenerating a damaged meniscus. Meniscus is exposed to a complex biomechanical microenvironment, and it plays a crucial role in meniscal development, growth, and repairing. Over the past decades, increasing attention has been focused on the use of biomechanical stimulus to enhance biomechanical properties of the engineered meniscus. Further understanding the influence of mechanical stimulation on cell proliferation and differentiation, metabolism, relevant gene expression, and pro/anti-inflammatory responses may be beneficial to enhance meniscal repair and regeneration. On the one hand, this review describes some basic information about meniscus; on the other hand, we sum up the various biomechanical stimulus based strategies applied in meniscus tissue engineering and how these factors affect meniscal regeneration. We hope this review will provide researchers with inspiration on tissue engineering strategies for meniscus regeneration in the future.

KEYWORDS:

biomechanical stimulus; meniscus; regeneration medicine; repair; tissue engineering

PMID:
29897012
DOI:
10.1089/ten.TEB.2017.0508
[Indexed for MEDLINE]

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