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Diabetes Obes Metab. 2018 Nov;20(11):2574-2584. doi: 10.1111/dom.13423. Epub 2018 Jul 11.

High-fat-diet-induced remission of diabetes in a subset of KATP -GOF insulin-secretory-deficient mice.

Author information

1
Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri.
2
Department of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri.

Abstract

AIMS:

To examine the effects of a high-fat-diet (HFD) on monogenic neonatal diabetes, without the confounding effects of compensatory hyperinsulinaemia.

METHODS:

Mice expressing KATP channel gain-of-function (KATP -GOF) mutations, which models human neonatal diabetes, were fed an HFD.

RESULTS:

Surprisingly, KATP -GOF mice exhibited resistance to HFD-induced obesity, accompanied by markedly divergent blood glucose control, with some KATP -GOF mice showing persistent diabetes (KATP -GOF-non-remitter [NR] mice) and others showing remission of diabetes (KATP -GOF-remitter [R] mice). Compared with the severely diabetic and insulin-resistant KATP -GOF-NR mice, HFD-fed KATP -GOF-R mice had lower blood glucose, improved insulin sensitivity, and increased circulating plasma insulin and glucagon-like peptide-1 concentrations. Strikingly, while HFD-fed KATP -GOF-NR mice showed increased food intake and decreased physical activity, reduced whole body fat mass and increased plasma lipids, KATP -GOF-R mice showed similar features to those of control littermates. Importantly, KATP -GOF-R mice had restored insulin content and β-cell mass compared with the marked loss observed in both HFD-fed KATP -GOF-NR and chow-fed KATP -GOF mice.

CONCLUSION:

Together, our results suggest that restriction of dietary carbohydrates and caloric replacement by fat can induce metabolic changes that are beneficial in reducing glucotoxicity and secondary consequences of diabetes in a mouse model of insulin-secretory deficiency.

KEYWORDS:

glucose metabolism; high fat diet; insulin resistance; insulin secretion; islets; β-cell function

PMID:
29896801
PMCID:
PMC6407888
[Available on 2019-11-01]
DOI:
10.1111/dom.13423

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