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Theranostics. 2018 Apr 18;8(11):2954-2973. doi: 10.7150/thno.24108. eCollection 2018.

Multimodality reporter gene imaging: Construction strategies and application.

Li M1,2, Wang Y1,2, Liu M1,2, Lan X1,2.

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Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Hubei Province Key Laboratory of Molecular Imaging.


Molecular imaging has played an important role in the noninvasive exploration of multiple biological processes. Reporter gene imaging is a key part of molecular imaging. By combining with a reporter probe, a reporter protein can induce the accumulation of specific signals that are detectable by an imaging device to provide indirect information of reporter gene expression in living subjects. There are many types of reporter genes and each corresponding imaging technique has its own advantages and drawbacks. Fused reporter genes or single reporter genes with products detectable by multiple imaging modalities can compensate for the disadvantages and potentiate the advantages of each modality. Reporter gene multimodality imaging could be applied to trace implanted cells, monitor gene therapy, assess endogenous molecular events, screen drugs, etc. Although several types of multimodality imaging apparatus and multimodality reporter genes are available, more sophisticated detectors and multimodality reporter gene systems are needed.


cell tracing; drug screening; gene directed therapy; molecular imaging; multimodality imaging; reporter gene

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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