Send to

Choose Destination
Front Psychiatry. 2018 May 29;9:223. doi: 10.3389/fpsyt.2018.00223. eCollection 2018.

Gut-Brain Axis and Mood Disorder.

Author information

Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.


Humans have over 100 trillion bacteria, highly abundant in the intestinal tract. Evidence suggests that intestinal microbiota is associated with the neuro-endocrine-immune pathways and can be associated with various mood disorders. This review summarizes findings from studies looking into neurobiochemical, neuroendocrine, and neuroimmune system mechanisms of the gut-brain axis to determine the relationship between intestinal microbiota and mood disorders. The effect of prebiotics, probiotics and antibiotics on mood disorders are also discussed, with the aim to propose some new therapeutic strategies for mood disorders.


gut–brain axis; intestinal microbiota; mood disorders; neuro-endocrine-immune; stress

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center