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Curr Protein Pept Sci. 2019;20(3):196-219. doi: 10.2174/1389203719666180613090710.

Research Progress of Bioactive Proteins from the Edible and Medicinal Mushrooms.

Author information

1
College of Chemical Engineering, Xiangtan University, Xiangtan, Hunan, 411105, China.
2
Department of History, Carnegie Mellon University, Pittsburgh, PA 15213, United States.
3
Department of Microbiology, The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, 300071, China.
4
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

Abstract

For centuries, mushrooms have been widely used as traditional Chinese medicine in Asia. Apart from polysaccharides and some small-molecule components, such as flavones, polyphenols and terpenes, mushrooms produce a large number of pharmaceutically active proteins, which have become popular sources of natural antitumor, antimicrobial, immunoenhancing agents. These bioactive proteins include lectins, laccases, Ribosome Inactivating Proteins (RIPs), nucleases, and Fungal Immunomodulatory Proteins (FIPs). The review is to summarize the characterstics of structure and bioactivities involved in antitumor, antiviral, antifungal, antibacterial and immunoenhancing activities of proteins from edible mushrooms, to better understand their mechanisms, and to direct research.

KEYWORDS:

Antimicrobial; Asia; antitumor; immunoenhancement; mushroom; protein.

[Indexed for MEDLINE]

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