Format

Send to

Choose Destination
Eur J Clin Invest. 2018 Aug;48(8):e12969. doi: 10.1111/eci.12969. Epub 2018 Jun 29.

Body height in paediatric inflammatory bowel diseases: A structural equation model analysis.

Author information

1
First Department of Pediatrics, "Aghia Sophia" Children's Hospital, University of Athens, Athens, Greece.

Abstract

BACKGROUND:

Linear growth restriction is a unique feature of paediatric inflammatory bowel diseases (IBD), and reduced insulin-like growth factor (IGF-1) is a major determinant of short stature. We aimed to assess factors influencing somatic height in children suffering from IBD.

MATERIALS AND METHODS:

This was a retrospective, cross-sectional study conducted after approval by Institutional authorities. Anthropometric data, disease-related factors, biochemical and clinical indices of inflammation and endocrine parameters were recorded and considered as explanatory covariates. A structural equation model analysis was utilized. Somatic height was the outcome of interest, and possible associations of explanatory covariates directly or through the mediation effect of IGF-1 were assessed.

RESULTS:

Systemic inflammation, as expressed by high-sensitivity intereukin-6 (IL-6), and nutritional status described by body mass index (BMI) were the pathways that significantly affected stature through the mediation effect of IGF-1. Cortisol showed a direct, positive and independent of IGF-1 association with height.

CONCLUSIONS:

Insulin-like growth factor-1 is a key player in the process that results in impaired linear growth. Malnutrition and systemic inflammation have a restrictive action on growth by reducing circulating IGF-1. The positive relation of serum cortisol to height could correspond to suppressed pituitary-adrenal axis due to long-term use of glucocorticoids.

KEYWORDS:

IGF-1; body height; inflammatory bowel diseases; mediation analysis; paediatrics

PMID:
29893990
DOI:
10.1111/eci.12969
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center