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Clin Infect Dis. 2019 Jan 1;68(1):139-142. doi: 10.1093/cid/ciy486.

Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy.

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Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam, The Netherlands.
Global Child Health Group, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
Department of Paediatrics and Child Health, Mulago Hospital, Makerere University College of Health Sciences, Kampala, Uganda.
Laboratory of Viral Immune Pathogenesis, Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.


A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

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