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Clin Infect Dis. 2019 Jan 1;68(1):139-142. doi: 10.1093/cid/ciy486.

Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy.

Author information

1
Laboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam, The Netherlands.
2
Global Child Health Group, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
3
Department of Paediatrics and Child Health, Mulago Hospital, Makerere University College of Health Sciences, Kampala, Uganda.
4
Laboratory of Viral Immune Pathogenesis, Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.

Abstract

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

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