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ACS Appl Mater Interfaces. 2018 Jul 5;10(26):21939-21949. doi: 10.1021/acsami.8b07213. Epub 2018 Jun 21.

Triple Stimuli-Responsive Magnetic Hollow Porous Carbon-Based Nanodrug Delivery System for Magnetic Resonance Imaging-Guided Synergistic Photothermal/Chemotherapy of Cancer.

Author information

1
College of Chemistry and Chemical Engineering , Central South University , Changsha 410083 , PR China.
2
Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science , Nanjing Normal University , Nanjing 210023 , PR China.
3
Jiangsu Key Laboratory of Biofunctional Materials , Jiangsu Engineering Research Center for Biomedical Function Materials , Nanjing 210023 , PR China.

Abstract

The premature leakage of anticancer drugs during blood circulation may the damage immune system, normal cells, and tissues. Constructing targeted nanocarriers with pH, glutathione, and NIR triple-responsive property can effectively avoid the leakage of anticancer drugs before they arrive at the targeted site. In this paper, magnetic hollow porous carbon nanoparticles (MHPCNs) were successfully fabricated as nanocarrier. Poly(γ-glutamic acid) was used to cap the pores of MHPCNs. The photothermal conversion property of carbon and iron oxide (Fe3O4) nanomaterials was utilized to perform photothermal therapy to overcome multidrug-resistance produced by chemotherapy. The biodistribution of nanoparticles was investigated by magnetic resonance imaging. Experiments in vivo confirm the efficient accumulations of nanoparticles at tumor sites. Meanwhile, tumor growth was effectively inhibited via synergistic photothermal/chemotherapy with minimal side effects.

KEYWORDS:

MHPCNs; MR imaging; PGA; synergistic photothermal/chemo-therapy; triple-responsive

PMID:
29893126
DOI:
10.1021/acsami.8b07213
[Indexed for MEDLINE]

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