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Sheng Wu Gong Cheng Xue Bao. 2018 May 25;34(5):653-663. doi: 10.13345/j.cjb.170395.

[Advances in Spt proteins and stress resistance of Saccharomyces cerevisiae].

[Article in Chinese; Abstract available in Chinese from the publisher]
Lu Z1,2,3, Lu Q3, Chen Y1,2,3, Wu R1,2,3, Huang J3, Chen X3, Chen D3, Huang R1,2,3.

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State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530005, Guangxi, China.
College of Life Science and Technology, Guangxi University, Nanning 530005, Guangxi, China.
National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China.


in English, Chinese

Spt proteins are defined as a large family of transcription regulators of the yeast Saccharomyces cerevisiae. They are crucial components of the SAGA complex that regulates transcription through interaction with the TATA box in the upstream region of the target genes. About 10% of total gene transcriptions are related to Spt proteins and these genes are highly related to environmental stress response. Such vast regulation network and complex mechanisms have become a hotspot. Spt proteins are also important to suppress transposon-induced mutations, being a switch on regulation of transposon behaviors and adaptive evolution of Saccharomyces cerevisiae. Besides that, some Spt proteins are directly involved in regulating unsaturated lipid acids synthesis, which could remold the cell membrane to resist environmental stresses. Here, we review Spt proteins, the advances in Spt proteins study, and their potential applications in improving yeast's stress resistance through transcription regulation, transposon activity regulation and cell membrane alternation.


SAGA complex; Spt; Spt23; membrane remolding; transposon

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