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Int J Surg Pathol. 2018 Dec;26(8):758-765. doi: 10.1177/1066896918777639. Epub 2018 Jun 11.

Calcifying Odontogenic Cyst Associated With Dentigerous Cyst in a 15-Year-Old Girl.

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1 Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
2 Instituto Mexicano del Seguro Social, Saltillo, Coahuila, México.
3 Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.


Calcifying odontogenic cyst (COC) is a rare odontogenic cyst with ameloblastic epithelial lining containing clusters of ghost cells. COCs have been described in association with several odontogenic tumors, more commonly odontomas and rarely with dentigerous cyst (DC). In this article, we describe a case of COC associated with DC in a 15-year-old girl, who presented with a swelling on the right middle third of the face, producing facial asymmetry. Panoramic radiography showed a well-circumscribed, corticated, and unilocular radiolucency at the level of the right maxillary sinus, involving 2 unerupted premolars. The lesion was enucleated and histologically revealed a COC associated with DC, which presented mucous metaplasia. Immunohistochemical reactions were performed to better illustrate this rare synchronous occurrence of COC and DC, showing positivity for CK5, CK14, CK19, and p63 in both lesions. CK18 was negative in COC, and Bcl-2 was negative in DC. Periodic acid Schiff highlighted the mucous cells in the DC lining.


calcifying odontogenic cyst; dentigerous cyst; ghost cells; immunohistochemistry; odontogenic cyst

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