Format

Send to

Choose Destination
Environ Res. 2018 Oct;166:215-222. doi: 10.1016/j.envres.2018.06.002. Epub 2018 Jun 8.

Maternal selenium status and neuropsychological development in Spanish preschool children.

Author information

1
Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO, Av. Catalunya 21, 46020 Valencia, Spain; School of Mathematics, University of Edinburgh, Peter Guthrie Tait Road, EH9 3FD Edinburgh, United Kingdom.
2
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain.
3
Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain.
4
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain; Department of Statistics and Operational Research, Universitat de València, Carrer del Dr. Moliner, 50, 46100 Burjassot, Spain.
5
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain; Department of Public Health, Universitat Miguel Hernández, Av. de Alicante KM 87, 03550 Sant Joan d´Alacant, Spain.
6
Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177 Stockholm, Sweden.
7
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Av. Monforte de Lemos, 3-5. Pabellón 11, 28029 Madrid, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Av. Catalunya 21, 46020 Valencia, Spain. Electronic address: llop_sab@gva.es.

Abstract

BACKGROUND:

The relationship between maternal selenium (Se) status and child neurodevelopment has been scarcely assessed. In a previous study we observed an inverse U-shaped association between maternal Se concentrations and infant neurodevelopment at 12 months of age. In this study, this non-linear association was explored at preschool age. The effect modification by breastfeeding, child's sex and cord blood mercury was also evaluated.

METHODS:

Study subjects were 490 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2012). Child neuropsychological development was assessed at around 5 years of age by the McCarthy Scales of Children's Abilities (MSCA). Sociodemographic and dietary characteristics were collected by questionnaire at the first and third trimester of gestation and at 5 years of age. Se was measured in serum samples by ICP-MS at the end of the first trimester of pregnancy (mean ± standard deviation (SD) = 12.4 ± 0.6 weeks of gestation).

RESULTS:

The mean ± SD of maternal serum Se concentrations was 79.9 ± 8.1 µg/L. In multivariate analysis, no linear association was found between Se concentrations and the nine MSCA scales. Generalized additive models indicated inverted U-shaped relationships between Se concentrations and the verbal and global memory scales. When assessing the influence of effect modifiers, breastfeeding played a role: the association between Se and neuropsychological development was inverted U-shaped for the quantitative, general cognitive, working memory, fine motor, global motor and executive function scales only for non-breastfed children.

CONCLUSION:

Low and high maternal Se concentrations seem to be harmful for child neuropsychological development, however further studies should explore this non-linear relationship.

KEYWORDS:

Children; Neurodevelopment; Nutrient; Pregnancy; Selenium

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center