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Ear Hear. 2019 Mar/Apr;40(2):219-226. doi: 10.1097/AUD.0000000000000614.

Recommendations on Collecting and Storing Samples for Genetic Studies in Hearing and Tinnitus Research.

Author information

1
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
2
Department of ORL, Head and Neck Surgery, Berlin Institute of Health, Berlin, Germany.
3
Otology & Neurotology Group CTS495, Department of Genomic Medicine, Centro de Genómica e Investigación Oncológica, Pfizer/Universidad de Granada/Junta de Andalucía (GENyO), Granada, Spain.
4
Institute of Human Genetics, Julius Maximilians University Würzburg, Würzburg, Germany.
5
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
6
Biosystems and Integrative Sciences Institute (BioISI), Lisbon, Portugal.
7
Biomedical Sciences Department, School of Health, Polytechnic Institute of Setubal, Setubal, Portugal.
8
Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
9
Department of Otolaryngology, Instituto de Investigación Biosanitaria, ibs.GRANADA, Hospital Universitario Virgen de las Nieves, Granada, Spain.

Abstract

OBJECTIVES:

Research on the genetic basis of tinnitus is still in its first steps. A group of scientists dedicated to tinnitus genetics within European Tinnitus Network (TINNET) network recognize that further progress requires multicenter collaborative efforts for defining contributing genes. The purpose of the present work is to provide instructions regarding collection, processing, storage, and shipment of samples intended for genetic studies in auditory research.

DESIGN:

One part of the recommendations has a general character; another part is of particular importance for auditory healthcare practitioners such as otolaryngology physicians, audiologists, and general practitioners.

RESULTS:

We provide a set of instructions and various options for obtaining samples. We give advice regarding sample processing, storage, and shipment and define the minimal and essential clinical information that should accompany the samples collected for genetic processing.

CONCLUSIONS:

These recommendations offer a basis to standardize and optimize collaborations between geneticists and healthcare practitioners specialized in tinnitus and hearing disorders.

PMID:
29889665
PMCID:
PMC6400449
DOI:
10.1097/AUD.0000000000000614
[Indexed for MEDLINE]
Free PMC Article

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