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Schizophr Bull. 2018 Aug 20;44(5):983-992. doi: 10.1093/schbul/sby082.

Toxoplasma gondii: Biological Parameters of the Connection to Schizophrenia.

Author information

1
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD.
2
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI.
3
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
4
Stanley Research Program, Sheppard Pratt Health System, Baltimore, MD.

Abstract

It is increasingly evident that the brain is not truly an immune privileged site and that cells of the central nervous system are sensitive to the inflammation generated when the brain is fighting off infection. Among the many microorganisms that have access to the brain, the apicomplexan protozoan Toxoplasma gondii has been one of the most studied. This parasite has been associated with many neuropsychiatric disorders including schizophrenia. This article provides a comprehensive review of the status of Toxoplasma research in schizophrenia. Areas of interest include (1) the limitations and improvements of immune-based assays to detect these infections in humans, (2) recent discoveries concerning the schizophrenia-Toxoplasma association, (3) findings of Toxoplasma neuropathology in animal models related to schizophrenia pathogenesis, (4) interactions of Toxoplasma with the host genome, (5) gastrointestinal effects of Toxoplasma infections, and (6) therapeutic intervention of Toxoplasma infections.

PMID:
29889280
PMCID:
PMC6101499
[Available on 2019-08-20]
DOI:
10.1093/schbul/sby082
[Indexed for MEDLINE]

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