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J Alzheimers Dis. 2018;64(1):269-279. doi: 10.3233/JAD-171059.

Relationships between Cognition and Activities of Daily Living in Alzheimer's Disease During a 5-Year Follow-Up: ALSOVA Study.

Author information

1
Department of Education and Psychology, University of Eastern Finland, Joensuu, Finland.
2
Institute of Clinical Medicine, Neurology, School of Medicine, University of Eastern Finland, Kuopio, Finland.
3
NeuroCenter, Neurology, Kuopio University Hospital, Kuopio, Finland.

Abstract

BACKGROUND:

Impaired cognition and activities of daily living (ADL) are core symptoms of Alzheimer's disease (AD), but their relationship is unclear.

OBJECTIVES:

To explore relationships between cognitive domains and functional ability during 5-year follow-up in persons with AD.

METHODS:

We analyzed ALSOVA study data from 236 individuals with very mild or mild AD at baseline. The CERAD Neuropsychological Battery (CERAD-NB) was used as a cognitive measure and Alzheimer's Disease Cooperative Study ADL (ADCS-ADL) as a functional measure, analyzing the IADL and BADL sub-scores separately. Annual regression models and linear mixed-effect models (LMMs) covering a 5-year follow-up period were used.

RESULTS:

Annually, the CERAD-NB total and especially Verbal Fluency, Clock Drawing, and Constructional Praxis were associated with the total ADCS-ADL and IADL scores increasingly yet modestly, and to a lesser extent the BADL score. In the LMMs, the same measures and MMSE were associated with ADL.

CONCLUSION:

Measures of executive function and visuoconstructive skills appear to be associated with caregiver-interview based ADL measure during the progression of AD.

KEYWORDS:

Activities of daily living; Alzheimer’s disease; cognition; dementia; follow-up study; functional ability

PMID:
29889073
DOI:
10.3233/JAD-171059
[Indexed for MEDLINE]

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