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Org Lett. 2018 Jul 6;20(13):3984-3987. doi: 10.1021/acs.orglett.8b01558. Epub 2018 Jun 11.

Synthetic Studies on the Natural Product Myrsinoic Acid F Reveal Biologically Active Analogues.

Author information

1
Research School of Chemistry , Institute of Advanced Studies, The Australian National University , Canberra , ACT 2601 , Australia.
2
Pharmaxis Ltd. , 20 Rodborough Road , Frenchs Forest , NSW 2086 , Australia.

Abstract

The synthesis of the structure, 1, assigned to the anti-inflammatory natural product myrsinoic acid F is reported together with a means for preparing its Z-isomer 21. While neither of these compounds corresponds to the natural product, both of them are anti-inflammatory agents (as determined using a mouse ear edema assay) with congener 1 being notably more potent than the widely prescribed NSAID indometacin.

PMID:
29888922
DOI:
10.1021/acs.orglett.8b01558
[Indexed for MEDLINE]

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