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Am J Cancer Res. 2018 May 1;8(5):866-878. eCollection 2018.

SOX5 interacts with YAP1 to drive malignant potential of non-small cell lung cancer cells.

Zou H1,2,3,4, Wang S1,2,3, Wang S2,3,5, Wu H3,6, Yu J1,2,3, Chen Q3, Cui W3, Yuan Y3, Wen X3, He J7, Chen L2, Yu R2, Zhang M2, Lan H2, Jin G3, Zhang X3, Bian X3, Xu C1,2,3.

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Department of Oncology, The Affiliated Hospital of Southwest Medical University Luzhou 646000, China.
Department of Oncology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China Chengdu 610072, China.
Institute of Pathology and Southwest Cancer Center, Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Southwest Hospital, Third Military Medical University Chongqing 400038, China.
Department of Oncology, The Third Affiliated Hospital of Chongqing Medical University Chongqing 400010, China.
Department of Oncology, Chengdu Military General Hospital Chengdu 610083, China.
Department of Experimental Research, Guangxi Medical University Nanning 530021, China.
Department of Respiratory, The First Affiliated Hospital of Third Military Medical University Chongqing 400038, China.


The dysregulation of transcription factors plays a vital role in tumor initiation and progression. Sex determining region Y-box 5 (SOX5) encodes a member of the SRY-related HMG-box family of transcription factors involved in the determination of the cell fate and the regulation of embryonic development. However, its functional roles in non-small cell lung cancer (NSCLC) remain unclear. Herein, we report that SOX5 sustains stem-like traits and enhances the malignant phenotype of NSCLC cells. We determine that SOX5 is preferentially expressed by cancer stem-like cells (CSLCs) of human NSCLC. In vitro gain- and loss-of-function studies demonstrate that SOX5 promotes self-renewal, invasion and migration in NSCLC cells. Importantly, knockdown of SOX5 potently inhibits tumor growth in a xenograft mouse model. Mechanistically, YAP1 can act as an interacting protein of SOX5 to drive the malignant potential of NSCLC cells. Silencing of YAP1 attenuates the malignant processes in NSCLC cells, which is consistent with the function of SOX5 loss. SOX5 overexpression reverses the attenuated malignant progression in YAP1 knockdown cancer cells. Taken together, these findings identify that SOX5 acts as an oncogenic factor by interacting with YAP1 in NSCLC cells and may be a potential therapeutic target for NSCLC patients.


SOX5; YAP1; invasion; migration; non-small cell lung cancer; self-renewal


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