Format

Send to

Choose Destination
J Clin Pharm Ther. 2018 Dec;43(6):903-905. doi: 10.1111/jcpt.12719. Epub 2018 Jun 9.

Probable pulmonary embolism with repeat administration of prothrombin complex concentrate in a factor Xa inhibitor patient.

Author information

1
Department of Pharmacy Services, Saint Joseph Hospital, Lexington, KY, USA.

Abstract

WHAT IS KNOWN AND OBJECTIVE:

Prothrombin complex concentrate (PCC) is a plasma-derived concentrate used to replenish clotting factors. There are limited recommendations for treating coagulopathy induced by direct oral anticoagulants (DOAC). Data are limited regarding both total dose and repeated dosing with this population.

CASE SUMMARY:

We describe a case of an adult patient anticoagulated with apixaban who received two 35 unit/kg doses of PCC resulting in suspected pulmonary embolism.

WHAT IS NEW AND CONCLUSION:

Treatment of DOAC-induced bleeding remains an "off-label" indication for PCC. Additional doses should be given with caution if given at all and patients monitored closely.

KEYWORDS:

anticoagulation; prothrombin complex concentrate; pulmonary embolism; repeat dosing; reversal

PMID:
29885249
DOI:
10.1111/jcpt.12719
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center