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Diagn Microbiol Infect Dis. 2018 Oct;92(2):164-167. doi: 10.1016/j.diagmicrobio.2018.05.012. Epub 2018 May 18.

Epidemiologic cutoff values to separate wild-type from non-wild-type Campylobacter fetus to ciprofloxacin.

Author information

1
Laboratoire de Bactériologie, Centre National de Référence des Campylobacters et des Hélicobacters, Place Amélie Raba Léon, 33076 Bordeaux, France.
2
Laboratoire de Bactériologie, Centre National de Référence des Campylobacters et des Hélicobacters, Place Amélie Raba Léon, 33076 Bordeaux, France; INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000, Bordeaux, France.
3
Laboratoire de Bactériologie, Centre National de Référence des Campylobacters et des Hélicobacters, Place Amélie Raba Léon, 33076 Bordeaux, France; INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000, Bordeaux, France. Electronic address: philippe.lehours@u-bordeaux.fr.

Abstract

The aim of the present study was to propose epidemiologic cutoffs that could be used in routine practice to separate wild-type from non-wild-type Campylobacter fetus to ciprofloxacin. A total of 123 C. fetus isolates obtained from human samples were used for this purpose. Based on the determination of inhibition zone diameter, minimum inhibitory concentration, and sequencing of the quinolone resistance determining region in the gyraseA gene, for all tested isolates, the following cutoffs were proposed: ciprofloxacin-wild type if the inhibition zone diameter was ≥22 mm or the minimum inhibitory concentration was ≤0.5 mg/L.

KEYWORDS:

Fluoroquinolones; MIC; Susceptibility testing; Zone diameter

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