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Environ Res. 2018 Nov;167:700-707. doi: 10.1016/j.envres.2018.02.031. Epub 2018 Jun 5.

Effects of mobile phone exposure on metabolomics in the male and female reproductive systems.

Author information

1
Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
2
Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey; Environmental Health Trust, 7100 N Rachel Way Unit 6 Eagles Rest, Teton Village, WY 83025, United States.
3
Hadassah Medical School, Hebrew University, Jerusalem, Isreal and Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey; Environmental Health Trust, 7100 N Rachel Way Unit 6 Eagles Rest, Teton Village, WY 83025, United States.
4
Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey. Electronic address: skaplan@omu.edu.tr.

Abstract

With current advances in technology, a number of epidemiological and experimental studies have reported a broad range of adverse effects of electromagnetic fields (EMF) on human health. Multiple cellular mechanisms have been proposed as direct causes or contributors to these biological effects. EMF-induced alterations in cellular levels can activate voltage-gated calcium channels and lead to the formation of free radicals, protein misfolding and DNA damage. Because rapidly dividing germ cells go through meiosis and mitosis, they are more sensitive to EMF in contrast to other slower-growing cell types. In this review, possible mechanistic pathways of the effects of EMF exposure on fertilization, oogenesis and spermatogenesis are discussed. In addition, the present review also evaluates metabolomic effects of GSM-modulated EMFs on the male and female reproductive systems in recent human and animal studies. In this context, experimental and epidemiological studies which examine the impact of mobile phone radiation on the processes of oogenesis and spermatogenesis are examined in line with current approaches.

KEYWORDS:

Mobile phone exposure; Oogenesis; Oxidative stress; Spermatogenesis

PMID:
29884548
DOI:
10.1016/j.envres.2018.02.031
[Indexed for MEDLINE]

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